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HIF-1 binds hypoxia response element (HRE) (Rashid et al., 2019) in promoter regions of target genes, influencing angiogenesis, cell proliferation, erythropoiesis, and cell metabolism (Hong et al., 2020), as well as a initiating inflammatory responses and compromising BBB integrity

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Some of the symptoms of Vitamin C deficiency (also known as scurvy) include: Easy bruising Dry, splitting hair and nails Slow-healing wounds Bleeding, inflamed, swollen gums Rough, dry, irritated skin Inexplicable weight gain Frequent nosebleeds What you can do about drug-induced Vitamin C depletion Minimize free radical generation Medications cause your body to produce unstable, potentially damaging free radicals