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However, in the heart, hyperacetylation of LCAD and -hydroxyacyl-CoA dehydrogenase has been observed to increase FA oxidation.36 Furthermore, deletion of cardiac SIRT3 increased acetylation of these enzymes and FA oxidation.36 Studies have also assessed acetylation on Krebs cycle enzymes, but they are limited and contradictory, with findings suggesting opposing effects of acetylation on the activity of a single enzyme.33 , 34 It is important to consider differences between studies, such as the tissue from which the mitochondria are isolated, differences between in vitro and in vivo acetylation, and how acetylation is mediated, which may account for the variation in results

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10.1016/j.phytochem.2006.05.012 22 CalmesB.Morel-RouhierM.Bataill-SimoneauN.GelhayeE.GuillemetteT.SimoneauP

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Formulation of nanoparticles using mixing-induced nanoprecipitation for drug delivery

Well-designed studies are still needed to clarify its role in the management of patients with SCD and to assess the safety of this approach (van Zuuren and Fedorowicz, 2015)