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In line with such results, also non-toxic digoxin-like synthetic derivatives (20,22-dihydrodigoxin-21,23-diol and digoxin-21-salicylidene) have been shown to specifically block IL-17 expression in human CD4 + T cells by inhibiting RORt activity 141

10.1016/j.devcel.2024.03.018 Dev Cell

This enzymatic system was first discovered in 1913 [39] and constitutes two cytosolic enzymes, glyoxalase-I (Glo-I, EC 4.4.1.5) and glyoxalase-II (Glo-II, EC 3.1.2.6.)

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The different results may be caused by species difference and different PA content in sperm, which need further study