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Conditions such as multiple sclerosis (MS), autoimmune encephalitis, and pediatric neuropsychiatric syndromes like PANS and PANDAS are characterized by an immune system that mistakenly targets the brain, leading to symptoms ranging from brain fog and fatigue to seizures, cognitive decline, and severe behavioral changes

8, 9, 10 The perception that a breach in the mucosal barrier incites mucosal inflammation is supported by the physical location of the intestinal epithelium, interposed as it is between the luminal contents and the mucosal surface (Figure 1)

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