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Description

Moir, S

They work mainly through appetite, satiety, gastric emptying, and metabolic signaling

V.VenturaH

PMID: 11472075 Adams GR, McCue SA

Native IGF-1 has a frustrating pharmacokinetic limitation: it binds tightly to a family of IGF binding proteins (IGFBPs, particularly IGFBP-3) that sequester it in circulation and keep its free half-life to roughly 15-20 minutes