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Because of the high heterogeneity of tumors, according to Darwinian evolutionary principles, drug-resistant mutants are selected, or subpopulations of primary resistant tumor stem cells in the dormant phase can cause tumors to regrow or spread

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References Hasin DS, Sarvet AL, Meyers JL, Saha TD, Ruan WJ, Stohl M, et al

CrossRef Ciprofloxacin enhances phototoxicity of 5-aminolevulinic acid mediated photodynamic treatment for chordoma cell lines Hanah Hadice Gull, Cihat Karadag, Brigitte Senger, Rdiger V