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Safety, Regulatory Status, and Contraindications: AOD-9604 is not FDA-approved and has not completed large-scale human efficacy trials

Doubling vitamin B12 intake was estimated to increase the vitamin B12 concentration in serum or plasma by 11% (95% CI: 9.4%, 12.5%) (Dullemeijer et al., 2013)

However, all research that has been done and published clearly states that its not so much the analogs that are the problem but rather the question of whether these animals are getting enough cobalt in their diet

In either case, the presence of large intestine bacteria in the small intestine can interfere with normal B12 levels