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At the same time, when POMC and AgRP neurons become resistant to insulin as a consequence of a high-fat diet, neurons expressing SF-1 within the ventromedial nucleus show increased sensitivity, which, in turn, translates into impaired glutamatergic innervation of POMC [49]

The authors declare that the funders had no role in the study design, interpretation of the data, the writing of this article or the decision to submit it for publication