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Results DMF activates the TSS pathway in SCD erythroblasts To investigate the mechanism of DMF on ferroptosis regulation, we conducted untargeted LC-MS using erythroblasts generated from CD34+ stem cells isolated from the peripheral blood of SCD patient

It is also generally the first amino acid to be depleted

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Neurologic symptoms of pellagra include headache, fatigue, apathy, depression, ataxia, poor concentration, delusions, and hallucinations, which can lead to confusion, memory loss, psychosis, and eventual death (27)

Mito-TEMPO (Sigma-Aldrich, Milan, Italy) was solubilized in DMSO and added to the cells simultaneously with the medium change 24 h before the viability assay

Under dual depletion of cystine and GSH, HepG2 cells underwent ferroptosis, characterized by a marked increase in lipid ROS and rescue effects of Fer-1 (Fig