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Beyond intracellular sensing via NODs, PGN-derived fragments function as potent signals that trigger the assembly of the NOD-like receptor protein 3 (NLRP3) inflammasome, leading to the maturation and secretion of IL-1

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doi:10.1016/j.psychres.2012.03.031 Maes M, Twisk FN, Kubera M, Ringel K (2012b) Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Increased interleukin-1, tumor necrosis factor-4a, PMN-elastase, lysozyme and neopterin

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