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This data suggests that 5-OP accumulation to 12-fold higher levels causes only a mild stress to the cell through multiple pathways which cumulatively leads to the growth defect in oxp1 strain

It acts as a cytoprotective agent, reducing oxidative stress and improving gastrointestinal repair

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However, STEP 1 extension concluded that 1-year withdrawal of semaglutide results in regain of two-thirds of prior weight loss [97], highlighting that withdrawal of semaglutide results in weight regain which may be problematic in older adults who are already using polypharmacy approaches for comorbid disease

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