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In a dose proportionality study involving multiple CMI doses, steady-state plasma concentrations (CSS) and area-under-plasma-concentration-time curves (AUC) of CMI and CMI's major active metabolite, desmethylclomipramine (DMI), were not proportional to dose over the ranges evaluated, i.e., between 25 to 100 mg/day and between 25 to 150 mg/day, although CSS and AUC are approximately linearly related to dose between 100 to 150 mg/day

Suggested Use Take 1 capsule daily with food or as directed by your healthcare provider

Efforts were made to minimize the use of animals and alleviate pain and discomfort

PMID 21284704

They used solid lipid nanoparticles (SLNs), carrying the poor water-soluble drugs, as oral delivery and conducted pharmacokinetic studies in rats

doi: 10.1016/j.ultsonch.2021.105686