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Consistent with this function, it has been shown that APAP induces autophagy both in primary mouse hepatocytes and intact liver and therefore the pharmacological promotion of autophagy by rapamycin protects against APAP hepatotoxicity (Ni et al., 2012a, 2013)

Measurement of FAD levels confirmed that WT FSP1 but not the D285N mutant is bound to FAD (Fig

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However, when evaluated in a phase II trial for recipients of kidney transplants 200 , RG7667 did not meet the primary end point within 12 weeks post-transplant

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