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FDA approval Phase 1, 2 and 3 clinical trials require companies to perform extensive clinical studies to determine drug safety and efficacy

[18] [19] It acts as an antagonist of the former two sites, and a partial co-agonist of the NMDA receptors

PMID: 41326809 Mol Psychiatry Stress induces behavioral disorders by promoting microglial phagocytosis via decreasing neuronal Dkk3

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Depressed participants were excluded for presence of the following: bipolar disorders, psychotic symptoms, history of psychosis outside of a mood episode, any eating disorder or post-traumatic stress disorder (PTSD) within one month of entering the study, and substance abuse or dependence (including alcohol) within six months of entering the study