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Th17/treg ratio and disease activity in systemic lupus erythematosus

doi: 10.1007/s12035-019-01712-8 21 DeanO.GiorlandoF.BerkM

Briefly, in a well described mechanism, paracetamol is broken down by membrane-bound cytochrome p450 enzymes such as CYP2E1, CYP1A2 and CYP3A4 to its reactive intermediate, NAPQI which is known to covalently bind to mitochondria and cause direct hepatic toxicity by prompting increased generation of ROS and reactive nitrogen species (RNS) that ultimately drive apoptosis and necrotic cell death [1, 72, 73]

All ETDs from UAB

These numbers are provided for research-use-only reference and are not medical or dosing advice

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