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Retatrutide, because it adds glucagon receptor activation, may cause additional metabolic effects that neither semaglutide nor tirzepatide produce, including greater fat oxidation and potentially different hunger pattern changes

In the SURMOUNT-1 trial, tirzepatide produced average weight loss of 15-22.5% of body weight over 72 weeks depending on dose

John's wort and Garcinia cambogia (HCA), may increase the risk of serotonin syndrome associated with SSRIs

Some patients experience mild nausea or headaches after their first injection, but these symptoms are usually temporary as your body adjusts