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Proc Natl Acad Sci USA 118(52)

PMID: 11028671

(2024) showed that CBD treatment reversed chemotherapeutic stress-induced depressive behaviors and noted that CBD inhibits iNOS expression via PPAR (Poudel et al

Chemically induced mouse models of intestinal inflammation

The accumulation of M1 macrophages triggers activation of JNK and IKK pathways through pattern-recognition receptor engagement, promoting insulin resistance through stress kinase signaling mechanisms (69, 70)