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In cultured hippocampal neurons, however, it seems that glutamate loading is associated with Cl efflux, and luminal Cl is critical for efficient vesicle acidification, indicating pivotal roles of luminal Cl on glutamate refilling in living synapses (Martineau et al., Regulation of Vesicular Glutamate Content by Cytoplasmic Cations Through Cation/H + Exchange Mechanisms on Svs Biochemical analysis of isolated SVs revealed that SVs exhibit an electro-neutral cation/H + exchange activity, which converts pH to , thereby facilitating glutamate transport into SVs (Goh et al., + exchange activity (Preobraschenski et al., Cytosolic Na + concentration is maintained at relatively low levels (~15 mM) by the activity of Na + /K + -ATPases on the plasma membrane

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Chen KH, Shao PL, Li YC, Chiang JY, Sung PH, Chien HW, Shih FY, Lee MS, Chen WF, Yip HK (2020a) Human umbilical cord-derived mesenchymal stem cell therapy effectively protected the brain architecture and neurological function in rat after acute traumatic brain injury

The depletion of the GSH store is believed to be due to the activity of Glo2, which is observed to be slower than Glo1 in astrocytes, thereby limiting the detoxification rate [111]

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