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New prospects for an old enzyme: mammalian cytochrome c is tyrosine-phosphorylated in vivo

doi: 10.1530/eje.0.1330425 128 FrieboesMurckAntonijevicSteiger

The top dose produced 20.9% average weight loss over 72 weeks and 20.2% in a direct comparison with semaglutides 13.7%. Its second receptor, GIP, separates tirzepatide from approved single-receptor GLP-1 drugs and helps explain the larger population-level weight loss. That 20.9% came from participants averaging about 105 kg at a BMI of 38, most of whom were sedentary

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Significant microbial growth that was discarded instead of being reported

Both produce satiety, but in different brain regions