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Direct cellular interactions and growth factor modulation: Peptides can interact directly with cell membranes, DNA or proteins to disrupt pathological processes or to deliver therapeutic cargo inside cells

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Hepatocytes that highly express SHH appear colocalized within fibrotic areas in livers of NASH patients (208), and are proximal to areas of hepatic progenitor cells (209), consistent with the observation that SHH signaling promotes and maintains a de-differentiated liver cell state (210)

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For analysis of spontaneous locomotion data, a two-way ANOVA was performed

Furthermore, changes in body composition, particularly with regard to muscle mass, may have influenced the energy expenditure findings, highlighting the need for longer-term studies to fully assess the effects of GLP-1 analogs on metabolism