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In this case, many pro-inflammatory cytokines, including TNF, interferon-, IL-1, IL-6, IL-18, and IL-33, are secreted in an unrestrained way causing a cytokine storm

For instance, the activities of NADPH dehydrogenase (complex I), succinic dehydrogenase (complex II) and cytochrome oxidize (complex IV) were lowered in three different regions of rat brain (cerebral cortex, mid brain and cerebellum)

Braz J Med Biol Res 40:839847

It was found that AGE-2 and AGE-3 accelerated retinopathy by upregulating vascular endothelial growth factor (VEGF) mRNA levels, as well as stimulating DNA synthesis and tube formation in microvascular endothelial cells via the interactions with RAGEs (12)

Hypertension-attributed nephropathy: what's in a name