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Upon binding, it activates a Gq-protein signaling cascade, leading to the production of inositol triphosphate (IP3) and diacylglycerol (DAG)

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The treatment of pregnant rats in late gestation with an inhibitor of KMO (Figure 1), results in an accumulation of kynurenine as well as promoting its transamination to kynurenic acid

[DOI] [PubMed] [Google Scholar] 220.Heald AH, Sharma R, Anderson SG, Vyas A, Siddals K, Patel J, Bhatnagar D, Prabharkaran D, Rudenski A, Hughes E, Durrington P, Gibson JM, Cruickshank JK

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A possible protective effect of nut consumption on risk of coronary heart disease: The adventist health study