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Graphical Abstract The graphical abstract depicts an overview of the pathways involved in the emergence of morphine-related tolerance and dependence including NMDA, Nitric oxide, and PPAR, as well as behavioural sensitization along with present and future innovative treatment strategies including stem cell therapy that have been discussed in the current manuscript

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FIGURE 1 Neutral lipids stored in LDs are primarily degraded by two pathways: lipophagy and lipolysis

doi: 10.1016/j.canlet.2017.03.008

& Mets-Ketel, M

and Carey/Pickart studies