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It was demonstrated that HG could cause the early activation of caspase-3/7 in SCs in vitro and in vivo , inducing caspase-dependent apoptosis in SCs ( in vivo study demonstrated that the apoptosis rate of RSC96 cells treated with HG for 48 h was increased by 9.72-fold, confirming that high glucose also elevated the mitochondrial pathway apoptosis-related Bax/Bcl-2 and cleaved caspase-9/caspase-9 ratios, and suggested that knockdown of histone deacetylase (HDAC1) could effectively inhibit HG-promoted mitochondrial apoptosis ( In addition to the above regulatory pathways, the role of HG on signaling pathways is critical in inducing apoptosis in SCs

CrossRef A Review of Research Trends in Traditional Korean Medicine for Nonalcoholic Fatty Liver Disease Na-yeon Kim, Mi-jung Yoon, Hong-sik Choi, Seung-mo Kim, Sang-chan Kim, Kyung-soon Kim The Journal of Internal Korean Medicine .2022

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Mol Cell 82:22282235

Based on the structural information, the residues that may be present as part of the ABS structure and functionality are marked with black rectangles, for the following discussion, only these residues are included

doi: 10.1016/j.sajb.2020.09.026 163 TijiSBenayadOBerrabahMEl MounsiIMimouniM