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Never discontinue prescribed medications without medical guidance, as abrupt cessation may worsen glycemic control or cause weight regain

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GSTM1 null deletion eliminates Mu-class glutathione S-transferase activity the enzyme conjugating electrophilic metabolites to GSH for excretion

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10.1126/science.276.5319.1709 12 BelbellaaB.ReutenauerL.MessaddeqN.MonassierL.PuccioH

In Figure3, we show model computations of the rates of the glucoronidation reaction, the sulfation reaction and the cytochrome P450 reaction in the liver at 0.5 hours after the dose for a range of doses