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Documenting the time of administration and the onset of sleep issues can help correlate and adjust the protocol

doi: 10.1056/NEJMra0910283 85 PalazonAGoldrathAWNizetVJohnsonRS

10.1182/blood-2006-12-065433 21 BoddupalliB

The renal susceptibility to crystal formation leads to various crystal nephropathies, primarily through CaOx-induced cytotoxicity in renal tubular epithelial cells

Fan et al., showed that tyrosine phosphorylation of JAM-A Y280 destabilized TJ-associated signalling elements, which resulted in decreased Rap2 GTPase activity and compromised epithelial barrier