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The co-expression of FOXP3 and glucocorticoid receptor (GR) was increased after TAT-GILZ treatment

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Conversely, hypoxia and glucose deprivation in the brain promotes HDAC9 expression in endothelial cells, which has been associated to decreased expression of ZO-1, claudin-5, and occludin (Shi et al., 2016)

Furthermore, research has demonstrated that reduced levels of 5mC and its oxidized form 5hmC, are inversely correlated with the accumulation of amyloid-beta (A) and phosphorylated tau proteins in AD (161)

While this approach can increase total GH output, it adds complexity and may not produce proportionally better results for most users