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Thus, dysfunctional activation of the UPR in melanocytes may cause more immunogenesis, which induces an attack on melanocytes in vitiligo

The genome-scale metabolic model of humans, Recon 2.2 19 , was expanded with the viral replication reaction for each of the three viruses

This depletes glutathione

In the BBB model with astrocytes, increased glutamine levels (Fig

In particular, curcumin increases the expression of GCL and other detoxifying enzymes via the activation of the nuclear factor E2-related factor 2 (Nrf2)-dependent pathway