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These results suggested that the upregulation of GPX1 promotes, while the deficiency of GPX1 suppresses, the survival of SGNs after peroxynitrite injury

Novel strategies under investigation include biomarker-guided therapy using circulating nitric oxide metabolites or endothelin-1 levels, and genetic profiling to identify responders to specific antihypertensive agents 48

DCI arises not only from large-vessel vasospasm, but also from other complex pathophysiological processes, including thrombo-inflammation, neuro-inflammation, microcirculatory dysfunction, and glycocalyx disruption