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Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors

These nanoparticles exert antitumor activity through the combined effects of erastin-induced ferroptosis and the Fenton reaction, both of which contribute to increased ferroptosis [159]

Abbreviations ACP1 - acid phosphatase CAT - catalase FMN - flavin mononucleotide GPX - glutathione peroxidase GSH - plasma reduced glutathione GSSG - oxidised glutathione MHR - methemoglobin reductase SOD - Zn/Cu superoxide dismutase TMR - transmembrane reductase of ferricyanide Methemoglobin reductase (MHR) is an erythrocyte cytosolic system responsible for reactivating haemoglobin's ability to transport oxygen after it has been converted into methemoglobin by reactive oxygen species (Board & Pidcock, 1981

However, other forms of HH, known as non-HFE haemochromatosis, also share the trait of having low plasma hepatic phospholipid levels that are out of proportion to the bodys iron levels

Zhang C, Li Q, Chen M, Lu T, Min S, Li S

Conversely, FDX1 causes the destabilization of Fe-S cluster proteins