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Further research is ongoing, but NNMT remains a high-interest target in metabolic science

[DOI] [PMC free article] [PubMed] [Google Scholar] 286.Shan, C

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Persistent cases warrant re-evaluation: advanced vestibular testing (VEMP, ENG), MRI to rule out central lesions, or referral to an otoneurologist

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5-Amino-1MQs confirmed high selectivity documented not to inhibit related SAM-dependent methyltransferases or NAD+ salvage pathway enzymes makes it the most validated small-molecule NNMT research tool currently available, and ensures that experimental findings can be reliably attributed to NNMT inhibition rather than off-target effects