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(2001) Proceedings of the National Academy of Sciences (PNAS) , 98(22): 1243812443 Foundational study demonstrating that peptides from the amino-terminal MDM-2 binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells, establishing the basis for PNC-27s design

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Abstract Metastatic disease in a cancer patient still remains a therapeutic challenge

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