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10.3389/fnmol.2019.00025 372 PreiningerovaJ

Article Snippet: Afterwards, the adherent cells were cultured with medium (1% autologous serum+ KBM581 +1000 U/mL rhGM-CSF (recombinant human granulocyte-macrophage colony-stimulating factor)+500 U/mL interleukin (IL)-4) for 48 hours, and then loaded with 13 neoantigen peptides (25 g/peptide) accompanied by certain cytokines (tumor necrosis factor alpha, 1000 U/mL

2020;6(1):e12050

NP targeting capability

& Tang, L

Nanoencapsulation allows the co-delivery of synergistic agents, such as GPX4 inhibitors (RSL3, FIN56), iron donors, and lipid peroxidation amplifiers, at reduced individual doses to circumvent toxicity thresholds and overcome resistance mechanisms [102, 103]