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At week 18, the ammonia recycling, Warburg effect, urea cycle, glycine and serine, glutamate, aspartate, arginine and proline, methionine, purine, glutathione, betaine, alanine, phenylalanine and tyrosine, amino sugar, cysteine, butyrate, histidine, selenoamino acid, nicotinate and nicotinamide metabolisms, citric acid cycle, pentose phosphate pathway, glucose-alanine cycle, cardiolipin biosynthesis, mitochondrial electron transport chain and transfer of acetyl groups into the mitochondria pathways were significantly altered in ALS compared to control cells (Fig

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Kobayashi M, Kobayashi S, Hayashi T, Tachibana M, Saito T, Ogura K, Miyakoshi S

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Clinical and biochemical outcome after hydroxocobalamin dose escalation in a series of patients with cobalamin C deficiency