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All factors which described above affects on the normal endothelium which plays an important role in the disturbing of normal homeostatic and causes endothelium dysfunction leads to progression of atherosclerotic plague formation (Russell, 1999)

J Physiol Pharmacol 2011;62(3):327-34

GSTP1 AA reference allele is associated with an increased risk for esophageal cancer in those having smoking habit 21 and laryngeal cancer in those having smoking and drinking habit 31

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