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However, the binding affinities of EGCG to HIF-1 and many other targets are higher than the EGCG plasma peak level in experimental animals administered with high dose of EGCG, raising a concern whether the microRNA regulation by HIF-1 is involved in the anti-cancer activity of EGCG in vivo

Yang H, Roberts LJ, Shi MJ

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In most cases of POAG, the disease may progress to total blindness without the patients experiencing any pain or discomfort, which however may occur when the rate of tension is very high, and IOP exceeds ~50 mm Hg