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Creatine and phosphocreatine have also been observed to be downregulated in the hippocampus of both rats and mice after one dose of ketamine [60, 61]

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As a naturally occurring compound in your body, supplemental glutathione supports existing biochemical pathways without introducing foreign substances

Proton magnetic resonance spectroscopy also showed a decrease in glutamate in the left ventrolateral prefrontal cortex, although these findings were not statistically significant

Notably, we observed lower levels of tissue coenzyme A (CoA), which has been considered to be extremely stable 10 , resulting in reduced mitochondrial functionality and metabolic rewiring