glutathione pathway metabolites Metabolism - an overview Figure 4 — Glutathione is

This adjustment to OS would result in low levels of mitochondrial ROS, increased mitochondrial respiration, and resistance to chemotherapy (Oliva et al., 2011)

2 Mitochondrial GSH import is mediated by SLC25A39

As a paradigm, Wu and co-workers integrated Au nanoclusters (Au NCs) with histidine to accomplish GSH exhaustive-prompted RT, denoted as Au NCs@His (Figure 7A) (Zhang et al., 2018)

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The lipid peroxidation is a free radical-driven reaction that primarily affects polyunsaturated fatty acids (PUFAs) in cell membranes, the product of which gradually increases during the ferroptotic cell death, from the initial lipid hydroperoxides (LOOHs) to the later production of malondialdehyde (MDA) and 4-hydroxynenoal (Kagan et al., 2017)

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