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Inter-species differences in drug metabolism, immune responses, and liver regeneration capacity can affect the translatability of findings, thereby restricting the extrapolation of preclinical data to clinical settings

Note: there are quite a few additional hormones that are involved in these processes, but for simplicity we are just focusing on the two primary female sex hormones

2018;183:491493 Anstee QM, Castera L, Loomba R

Inverted repeats are necessary for circularization of the mouse testis Sry transcript