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Under nutrient-rich conditions, TORC1 signaling activates the Rpd3L HDAC complex, which deacetylates INO80 and H2A.Z, resulting in reduced chromatin accessibility at ATG promoters and the suppression of their expression

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Per via orale, nelle deficienze primarie e secondarie a malattie genetiche, il dosaggio varia in base allet: nei bambini piccoli si calcola in mg/kg, mentre negli adulti si parla generalmente di 2-4 grammi al giorno secondo gravit della patologia