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Conclusions Changes in intra-portal insulin levels play an intricate yet permissive role in the regulation of the GH/IGF-I axis by either stimulating or suppressing hepatic GH sensitivity and hepatic IGF-I generation, probably via an insulin-mediated regulation of the hepatic GHR expression

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Our previous study has revealed that the gene expression of mitochondrial biogenesis markers ( PGC1 , NRF1 , and TFAM ) and mtDNA-encoded OXPHOS genes are all downregulated in the skeletal muscle of SLD chickens and GHR knockdown cells (Hu et al., 2019)

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