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Young males displayed also higher NADP + /NADPH ratio in frozen blood compared to age-matched females, while NADH and GSSG were higher and GSH/GSSG ratio lower in 31-40 years old males compared to females (Supplementary figure 2i-s)

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One such mechanism, active in mammalian stem cells, is to prevent illegitimate transcription initiation outside of promoter regions, at intragenic cryptic start sites, particularly within genes that are highly expressed 50,52

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A comprehensive literature search yielded 153 studies, 13, published from 1989-2007, were deemed eligible