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Bone, lung, liver, and brain are the most frequent metastatic sites, and each sites possess different microenvironments to favor survival of metastasizing cancer cells [ Figure 3I ] (186, 187)

J., Lilla, S., Hedley, A., Koulouras, G., McGregor, G., Jamieson, C., Johnson, R

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The reduction of mitochondrial ROS production dramatically decreases the cross-presentation capacity of pDCs, leading to a strong reduction of their capacity to trigger CD8 + T cells responses (101)