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Fex M, Olofsson CS, Fransson U, Bacos K, Lindvall H, Sorhede-Winzell M, Rorsman P, Holm C, Mulder H: Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact

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This functional diversity is often studied using the M1/M2 polarization model, which provides a valuable in vitro framework for distinguishing between pro-inflammatory and pro-resolving states