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Moreover, it was observed that the intracellular Fe 2+ level increased in TBH-treated ARPE-19 cells but that there was no significant change in Fe 2+ after pretreatment with FER-1 or deferoxamine (DFO) ( In neovascular AMD, RPE cells generate vascular endothelial growth factor (VEGF) when they are under hypoxia or oxidative stress ( 2+

Godlewska et al

It has been proved that BaP reduced genome-wide DNA methylation, and activated proto-oncogene by hypomethylation in the promoter region, but silenced tumor suppressor genes by promoter hypermethylation, resulting in cancer initiation and progression

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"Antimicrobial actions of reactive oxygen species"

doi: 10.1016/j.rmed.2008.11.009