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The heterogeneity of TME in GBM shows considerable variability, and the crosstalk between malignant cells and microenvironment is critical for tumor cell proliferation and migration, contributing to the suppression of infiltration and activation of T cells

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The combination of CBD with oxaliplatin has been shown to suppress eNOS phosphorylation and NO levels, triggering ROS-mediated autophagy and restoring tumor sensitivity to chemotherapy (Jeong et al