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Secondly, the use of humanized mice to establish patient-derived xenograft (PDX) models can provide a research model that is closer to the real internal environment of the human body, but it is costly and time-consuming

R., Shi, B., Varga, J

"Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity"

Khanna D, Spino C, Johnson S, Chung L, Whitfield ML, Denton CP, Berrocal V, Franks J, Mehta B, Molitor J, Steen VD, Lafyatis R, Simms RW, Gill A, Kafaja S, Frech TM, Hsu V, Domsic RT, Pope JE, Gordon JK, Mayes MD, Schiopu E, Young A, Sandorfi N, Park J, Hant FN, Bernstein EJ, Chatterjee S, Castelino FV, Ajam A, Wang Y, Wood T, Allanore Y, Matucci-Cerinic M, Distler O, Singer O, Bush E, Fox DA, Furst DE (2020) Abatacept in early diffuse cutaneous systemic sclerosis: results of a Phase II investigator-initiated, multicenter, double-blind, randomized

The finding outlines the importance of determining biomarkers to predict the efficacy of VEGF-targeted therapies