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(i) at low concentrations, it can prevent the oxidation of the substrate (ii) the radical generated on the polyphenols must be stable enough so that it can prevent itself from acting as a chain-propagating radical (Dangles, 2012)

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Cytoplasmic Zn promotes IL-1 production and subsequently inhibits inflammation, depending on the transcription factor NF-B, an inflammatory activating factor (104)

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TRPV1 acts as a synergistic, but not essential, contributor to this process