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G.GratadouxJ

In the cytosol, NADPH is mainly produced by the pentose phosphate pathway (e.g., in S

Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neurons

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Recent studies have also reported that POR and CYB5R1 can transfer electrons from NAD(P)H to oxygen to generate the H 2 O 2 , which subsequently reacts with iron to generate hydroxyl radicals for further promoting the peroxidation of PUFA of PLs-PMs, thereby disrupting membrane integrity and leading to ferroptosis [40, 41]