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When that surveillance is disrupted, previously dormant organisms may proliferate or amplify inflammatory signaling

This characteristic means deficiency develops slowly, often taking years to manifest

There's not enough evidence to say whether ALA is effective for these purposes

Biogerontology 16(6):693707 Chai Z, Gatti S, Toniatti C, Poli V, Bartfai T (1996) Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1: a study on IL-6-deficient mice